In this free webinar, gain insight into why the majority of DNA-encoded library (DEL) data has historically been ignored, and what is being missed. Attendees will learn how chemomic approaches transform full DEL output into deep structure-activity relationship (SAR), structure-function maps and early mechanistic insights. The featured speakers will discuss how front-loaded data improves the understanding of target biology and candidate selection and reduces downstream risk. The speakers will also share how chemomics fits within modern discovery workflows. Attendees will learn how DEL, computational sciences and unmatched expertise can help launch more informed and successful programs.
TORONTO, Sept. 11, 2025 /PRNewswire/ — DNA-encoded library (DEL) screening has become a standard tool in small-molecule drug discovery. Yet, even as its adoption for hit finding grows, the vast amounts of data it generates are generally overlooked. More than 99% of the information produced during a DEL screen is typically neglected in favor of choosing a handful of hits to synthesize and test. That ignored data holds incredible, untapped insight into molecular interactions, structure–activity relationship (SAR) trends, mechanism of action (MOA) and potential risks that can radically influence compound progression.
This webinar will explore chemonics, a framework for unlocking the full power of DEL data. Built on a highly validated DEL platform and enhanced by computational sciences, this approach will shift how discovery teams approach early-phase decision-making and will transform raw screening output into structured, decision-ready insight before synthesis even begins.
The featured speakers will explore how chemomics works, why it matters and how it changes the economics and efficiency of small molecule discovery. Rather than relying on a narrow set of enriched binders, chemomic analysis entails full-selection data to identify meaningful SAR patterns, visualize structure–function relationships and guide discovery programs with clarity from the outset — all before synthesis begins.
Attendees will gain a deep understanding of how chemomic approaches deliver mechanistic insight across multiple chemical series, dramatically improving the starting point for hit-to-lead efforts. Beyond guiding better hit selection, chemomics integrates iterative feedback from hit synthesis and validation to refine SAR hypotheses and generate new, higher-potential compound suggestions. This enables dynamic optimization of lead series, not just selecting better starting points, but actively evolving them. This session will highlight the value of early data-driven triage and how a more complete picture of the DEL landscape helps avoid costly downstream surprises.
This is not just a technology update. It is a new mindset for discovery. Chemomic approaches represent a departure from conventional screening and hit validation models. By applying comprehensive DEL data to work earlier, discovery programs can be front-loaded with years of SAR for multiple MOAs, allowing researchers to make more confident decisions, reduce program risk and unlock candidates with greater therapeutic potential.
Whether experienced as a DEL practitioner or exploring how to improve hit program efficiency, this session will offer a forward-looking perspective on what discovery should look like in the data-driven era.
Register for this webinar to learn how DNA-encoded library data can be harnessed through chemomics to accelerate and refine small molecule discovery.
Join experts from X-Chem, Matt Clark, PhD, Chief Scientific Officer; and Erin Davis, PhD, Chief Technology Officer, for the live webinar on Thursday, October 2, 2025, at 11:30am EDT (4:30pm BST/UK).
For more information or to register for this event, visit DNA-Encoded Library Data: Unlocking Chemomic Insights for Drug Discovery.
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